Los Angeles, 2049: in a hyper-technological and overpopulated city, KD6-3.7 is a Nexus 8, an improved Replicant from the previous Nexus 6 (androids physically humans, but smarter and stronger) that in 2019 they were pursued and retired by special agents named Blade Runners, who works himself as Blade Runner retiring the remnants of the Nexus 6, living with a lovely home hologram named Joi as only one company. In his last case to locate and retire a replicant named Sapper Morton, K finds traces of a burial close to Morton's home, and he unearths a mysterious box where are discovered the mortal remains of Rachael, a replicant who was missing since 2019 after she fled with a Blade Runner, Rick Deckard. Discovering too the impossible that Rachael was pregnant and that possibly her child could be alive, Lieutenant Joshi orders K to find and destroy Rachael's descendant before the news be known to the public eye and it causes a mass hysteria. But this revelation is known by blind scientist Niander Wallace, owner of Wallace Corp., creator and manufacturer of the Nexus 8 (heir of the previous Tyrell Corp. that manufactured Nexus 6 that it collapsed during a world blackout in 2022), who is obsessed to create replicants able to bring new life. Unknown for K, Wallace orders to his personal assistant, a Nexus 8 named Luv, to find Deckard for that he reveals him the location of the child he had with Rachael. But the mission complicates for K when he starts to question about his own false memories, doubting if himself could be Deckard's child and not the replicant that he thought to be. As well as K's investigation progresses and his steps points Deckard, Luv's steps points K, in a race against the clock to see who finds Deckard first.