Ates Hekimoglu is a successful doctor in his 40s. He is working as Infectious Diseases and Nephrology Specialist in the hospital where his friend Ipek is in charge. The most well-known characteristic of Ates Hekimoglu is that he conducts research by focusing on diseases without establishing one-to-one relationships with patients. Each new complex case is provocative and exciting, like a puzzle waiting for him to be solved. While Ates Hekimoglu increases his reputation day by day with his diagnoses and treatments, his inability to keep up with the hospital layout often leaves the hospital administrator Ipek in a difficult situation. Ipek is one of the two people who understands and can tolerate Hekimoglu's tough character. The other is Orhan, the Oncology Specialist of Hekimoglu's friend from high school and university. Hekimoglu examines the diseases as a detective and carries out these studies together with a team of 3 specialist doctors. These 3 specialist doctors selected by Ates Hekimoglu are making efforts to please him.